Objective   To study and analyze the level of plateau recuperation support after follow-up investigation on the post recuperation effects of plateau officers and soldiers.Methods   In July 2023,a follow-up survey was conducted on 57 convalescent personnel from a plateau military unit,who were divided into three groups:15 at an altitude of 3 000~4 900 meters,23 at an altitude of 5 000~5 300 meters,and 19 at an altitude of 5 380~5 426 meters.Questionnaire surveys,testing,and follow-up studies were conducted to analyze the effects of recuperation on plateau officers and soldiers.Results   Special treatment for recuperation personnel accounted for 54.4%,while health and specialized treatment accounted for 42.1%.The pulse,respiration,systolic blood pressure,and diastolic blood pressure of each group were all within the normal range,and the oxygen saturation was low,with an average of(90.95±6.50)%.Plateau officers and soldiers had a great demand for recuperation and high satisfaction,and supported special treatment arrangements for personnel above 4 000 meters in altitude.The effects of rehabilitation for plateau officers and soldiers were significant,which were reflected in the reduction of symptoms of altitude sickness,and significant increase in understanding of plateau conditions and personal health maintenance.After recuperation,the life style was improved,the psychological condition was adjusted and the influence of illness on work was reduced.Conclusion   Plateau officers and soldiers have great demand for convalescence,and the after-effect of recuperation is obvious.In the future,we can strengthen the implementation of the plateau recuperation security system,carry out research on the plateau recuperation security measures,further improve the after-effect of recuperation,and provide a strong guarantee for improving the military operation ability and health maintenance of officers and soldiers on the plateau.

Objective   To explore the internal relationship among sleep quality,mindfulness practice and mental health among officers and soldiers in plateau-stationed training mission.Methods   A total of 437 officers and soldiers were recruited to participate in the study.According to standardized sleep quality assessment criteria,they were divided into two groups:good sleep quality group and poor sleep quality group.Basic demographic data were collected for all participants and their mindfulness practice and mental health scores on the symptom checklist (SCL-90) were carefully assessed.Multivariate Logistic regression analysis was used,and the potential relationship between them was further clarified by mediating effect analysis.Results   ①The good sleep quality group had a higher rate of mindfulness practice and a lower rate of SCL-90 positive score.In contrast,those in the poor sleep quality group were on average older,had more years in the military,and generally had higher levels of education.②Multivariate Logistic regression analysis confirmed that poor sleep quality was an independent factor leading to poor mental health.At the same time,mindfulness practice was negatively associated with poor mental health risk.③The mediating effect analysis revealed the mediating role of sleep quality between mindfulness practice and mental health.Sleep quality plays a partial mediating role in this relationship,that is,mindfulness practice has a positive effect on mental health by affecting sleep quality.Conclusion   The results of this study suggest that mindfulness practice and good sleep quality are indispensable elements to maintain mental health of the officers and soldiers in plateau-stationed training.Therefore,promoting the relevant training of mindfulness practice to improve the sleep quality of officers and soldiers is expected to be an effective way to improve the mental health of officers and soldiers in plateau-stationed training.

Objective   To observe the effects of Qihong Bufei Decoction on the pulmonary arterial pressure in rats with hypoxic pulmonary arterial hypertension(HPAH),and to explore its mechanism.Methods   Totally forty male Sprague-Dawley(SD) rats were randomly divided into four groups:normoxia group(N),HPAH group(H),Qihong Bufei Decoction group(T) and Qihong Bufei Decoction+Compound C group(T+C),with 10 rats in each group.Rats in the H group,T group and T+C group received hypobaric hypoxia to establish the HPAH model,followed by drug intervention correspondingly.The mean pulmonary artery pressure(MPAP),right ventricular systolic pressure(RVSP),and right ventricular hypertrophy index(RVHI) were measured after the intervention.The internal ultrastructure of lung tissue was observed by transmission electron microscopy(TEM).The protein levels of AMP-activated protein kinase(AMPK),mammalian target of rapamycin(mTOR),P62,Beclin1l,and light chain 3B(LC3B) in the lung tissue were detected by Western blot.Results   Compared with the N group,MPAP,RVSP and RVHI significantly increased in H group(all P<0.05).Compared with the H group,MPAP,RVSP and RVHI were significantly lower in the T group(all P<0.05).Compared with the T group,MPAP,RVSP and RVHI were significantly higher in the T+C group(all P<0.05).Compared with the N group,activated autophagy was observed in the H group,which was more pronounced in the T group but significantly inhibited in the T+C group.The protein expressions of p-AMPK,Beclin-1 and LC3B were significantly up-regulated in the H group than the N group(all P<0.05),while the levels of p-mTOR and P62 protein expression were down-regulated(all P<0.05).Compared with the H group,protein levels of p-AMPK,Beclin-1 and LC3B were further upregulated,and p-mTOR and P62 were downregulated in the T group(all P<0.05).Protein levels of p-AMPK,Beclin-1 and LC3B were significantly downregulated,and p-mTOR and P62 were upregulated in the T+C group than the T group(all P<0.05).Conclusion   Qihong Bufei Decoction can reduce pulmonary artery pressure and attenuate right ventricular hypertrophy in HPAH rats by inducing autophagy via activating the AMPK/mTOR pathway.

Objective   To investigate the effect of elastic band training in patients with pneumoconiosis after low volume lung lobe lavage.Methods   A total of 110 pneumoconiosis patients admitted to Ganzhou Fifth People's Hospital from June 2021 to June 2023 were divided into two groups with 55 cases in each group by random number table.The control group was treated with low volume lung lobe lavage,and the observation group was given elastic band training on the basis of the control group.Lung function,blood gas index,exercise ability and quality of life were compared between the two groups.Results   There was no statistically significant difference(P>0.05) in lung function [maximum ventilation volume per minute(MVV),forced expiratory volume in one second(FEV1),forced vital capacity(FVC)],blood gas indicators,exercise ability,and quality of life between the two groups before intervention.After intervention in both groups,lung function,arterial oxygen partial pressure (p[O2]) levels,6-minute walking distance(6MWD),and motor function Fugl-Meyer assessment(FMA) scores all increased,while arterial carbon dioxide partial pressure (p[CO2]) levels and COPD(chronic obstructive pulmonary disease) assessment test(CAT) scores decreased,with difference of statistical significance(P<0.05).After intervention,the FEV1(2.91±0.35) L,FVC(4.68±0.42) L,and MVV(4.95±0.28) L in the observation group were all higher than those in the control group(2.38±0.27) L,(3.87±0.35) L,and(4.01±0.22) L,and the differences were statistically significant(P<0.05).After intervention,the p(CO2)(45.38±2.41) mmHg(1 mmHg=0.133 kPa) level in the observation group was lower than that in the control group(52.16±3.67) mmHg,and the p(O2)(75.21±5.96) mmHg level was higher than that in the control group(68.94±5.25) mmHg,with difference of statistical significance(P<0.05).After intervention,the observation group had higher 6MWD(352.53±33.05) m and FMA score(82.41±6.42) than the control group(316.21±30.07) m and(74.35±5.71),while the CAT score(11.38±1.67) was lower than the control group(14.36±2.52),with difference of statistical significance(P<00.05).Conclusion   For patients with pneumoconiosis after low volume lung lobe lavage,the effect of elastic band training is better,which can improve the blood gas index of patients,recover the lung function and exercise ability better,and thus improve the quality of life.

Objective   To observe the application value of buccal acupuncture therapy in improving postoperative stress response and gastrointestinal reaction in patients with total hysterectomy.Methods   This is a prospective study.100 patients undergoing total hysterectomy admitted to Kaifeng Obstetrics and Gynecology Hospital from January 2022 to February 2024 were selected as research objects by double-blind method.Random sequences were generated by computer randomization method and assigned and hidden,and the enrolled patients were classified into conventional group(50 cases) and buccal acupuncture group(50 cases),respectively.Conventional general anesthesia was given to the conventional group,and general anesthesia assisted by buccal acupuncture therapy was given to the buccal acupuncture group.Perioperative hemodynamics,perioperative pain,postoperative stress indexes and gastrointestinal adverse reactions were compared between the two groups.Results   There was no significant difference in heart rate(HR) and mean arterial pressure(MAP) at 5 min(T1) after induction between the buccal acupuncture group and the conventional group under different anesthesia schemes(P>0.05).The HR of the buccal acupuncture group of T2(at intubation) and T3(at the end of operation) were(77.69±10.24) times /min and(75.33±10.21)times/min,respectively,lower than those of the conventional group([83.23±10.46]times/min and [80.44±10.27] times/min).MAP values of (110.25±20.43)mmHg(1 mmHg=0.133 kPa) and (109.45±20.49)mmHg were lower than those of the conventional group ([126.33±20.37]mmHg,[124.14±20.45]mmHg),P<0.05;The amount of propofol,the amount of remifentanil,the visual analogue scale(VAS) at 30 min after operation,and the number of postoperative patient controlled intravenous analgesia(PCIA) compressions in the buccal acupuncture group were(30.23±5.16)mg,(1.22±0.34)mg,(2.75±0.22)scores and(1.55±0.27) times, respectively,lower than the conventional group ([33.29±5.41]mg,[1.85±0.36]mg,[3.28±0.46]scores,[2.14±0.37]times),P<0.05; Norepinephrine(NE),cortisol(Cor),angiotensin Ⅱ(Ang Ⅱ),prolactin(PRL) in the buccal acupuncture group were(42.25±10.27)μg/L,(282.46±20.34)nmol/L,(27.55±5.15)ng/L,and(13.23±3.16)μg/L respectively,lower than those in the conventional group ([47.23±10.35]μg/L,[294.25±20.41]nmol/L,[30.22±5.36]ng/L,and[15.44±3.23]μg/L),P<0.05;The incidence of gastrointestinal adverse reactions in thebuccal acupuncture group was 4.00%(2/50),lower than that in the conventional group 22.00%(11/50),P<0.05.Conclusion   General anesthesia assisted by buccal acupuncture therapy can stabilize perioperative hemodynamics in patients with total hysterectomy,and has positive significance in enhancing analgesic effect,alleviating postoperative stress reaction and reducing the risk of gastrointestinal adverse reactions.

Objective   To observe the clinical effect of centering acupuncture combined with cognitive behavioral therapy on children with attention deficit and hyperactivity disorder(ADHD).Methods   A total of 86 children with ADHD admitted to the Fifth Affiliated Hospital of Zhengzhou University from January 2023 to August 2024 were selected and divided into two groups by random number table.The control group was given cognitive behavioral therapy intervention,and the observation group was given centering acupuncture intervention on the basis of cognitive behavioral therapy.The changes of electroencephalogram(EEG) index and average cerebral artery blood flow velocity in the two groups were detected before and after treatment,and the differences of Chinese revised Wechsler Intelligence Scale for Children(C-WISC) score and Swanson,Nolan,and Pelham,version IV scale(SNAP-Ⅳ) score were evaluated between the two groups before and after treatment.Results   There was no difference of statistical significance in EEG index between the two groups before treatment(P>0.05).After treatment,β wave and sensorimotor rhythm(SMR) in both groups were higher than those before treatment,and β wave and SMR in the observation group were higher than those in the control group(P<0.05).After treatment,θ wave in both groups was lower than that before treatment,and θ wave in the observation group was lower than that in the control group(P<0.05).There was no difference of statistical significance in C-WISC score and SNAP-Ⅳ score between the two groups before treatment(P>0.05).After treatment,PIQ(performance intelligence quotient)scores,VIQ(verbal intelligence quotient) scores and FIQ(full intelligence quotient) scores were higher than those before treatment,and C-WISC scores in the observation group were higher than those in the control group(P<0.05).The scores of hyperactivity/impulsivity symptoms and attention deficit symptoms after treatment were lower than those before treatment,and the SNAP-Ⅳ scores in the observation group were lower than those in the control group(P<0.05).There was no difference of statistical significance in average cerebral artery blood flow velocity between the two groups before treatment(P>0.05).After treatment,the bilateral middle cerebral artery(MCA),anterior communicating artery(ACA) and posterior cerebral artery(PCA) in the observation group were higher than those before treatment,and the average cerebral artery blood flow velocity in the observation group was higher than that in the control group(P<0.05).Conclusion   Centering acupuncture combined with cognitive behavioral therapy can improve EEG and average cerebral artery blood flow velocity and alleviate symptoms of ADHD.

Objective   To investigate the effect of multimodal somatosensory motor therapy applied to postoperative patients with thyroid cancer.Methods   A total of 87 patients with thyroid cancer after surgery in the Department of Surgery of Puyang Hospital of Traditional Chinese Medicine were selected from May 2022 to May 2023.They were divided into study group and control group by random number table,with 44 cases and 43 cases respectively.The control group received routine intervention after surgery,and the study group added multimodal somatosensory motor therapy on the basis of the control group.Fatigue degree (fatigue scale 14[FS-14]) quality of life(EORTC QLQ-C30) and exercise compliance were compared between the two groups at 4,8 and 12 weeks of intervention.Results   With the extension of time,the FS-14 score of both groups decreased,and the FS-14 score of the study group was lower than that of the control group(P<0.05).After 12 weeks of intervention,the functional domain scores (17.69±2.17) and general health status domain scores (5.34±1.19) of the study group were higher than those of the control group (16.54±2.15) and (4.69±1.03).Symptom domain scores (6.56±2.11) and single measurement item scores (13.17±3.12) were lower than those of the control group(7.96±2.01) and (14.76±3.23),P<0.05.After 4,8 and 12 weeks of intervention,the exercise completion rate of the study group was higher than that of the control group(P<0.05).Conclusion   For patients with thyroid cancer after surgery,multimodal somatosensory motor therapy can improve the fatigue tolerance of patients after surgery,improve the quality of life after surgery,and promote the enthusiasm of patients after surgery.

Objective   To explore the application of three-dimensional five-sense awakening therapy combined with median nerve electrical stimulation to severe craniocerebral injury.Methods   A total of 96 patients with consciousness disorder following severe craniocerebral injuries were selected from the Department of Neurosurgery of the Third People's Hospital of Zhengzhou from August 2021 to August 2023.They were divided into the control group(48 cases) and study group(48 cases) by drawing lots.The control group was given median nerve electrical stimulation,and the study group was given the three-dimensional five-sense awakening therapy combined with median nerve electrical stimulation.After six months of treatment,the recovery status(the modified coma recovery scale[CRS-R]),coma degree(the Glasgow coma scale[GCS]), the disability rating scale(DRS),neuroelectrophysiological changes(brainstem auditory evoked potential[BAEP],somatosensory evoked potential[SEP],electroencephalogram[EEG]),cerebral hemodynamic parameters(cerebral arterial systolic blood flow velocity[VS],mean blood flow velocity[VM],pulse index [PI]) and neurological dysfunction were compared.Results   After treatment,the CRS-R([15.67±2.13]points VS [11.88±2.12]points),GCS([12.67±1.43]points VS [9.88±1.12]points) and DRS([14.98±2.52]points VS [11.67±2.63] points) scores of the study group were significantly higher than those of the control group(P<0.05).The BAEP([1.43±0.19] VS [1.88±0.54]),SEP([1.48±0.23] VS [1.79±0.25]) and EEG([1.64±0.33] VS [2.99±0.89]) in the study group were significantly lower than those of the control group(P<0.05).VS and VM in the study group were significantly higher than those of the control group,and PI was significantly lower than that in the control group(P<0.05).Conclusion   Three-dimensional five-sense awakening therapy combined with median nerve electrical stimulation can promote recovery,reduce the severity of coma,improve nerve electrophysiological changes and cerebral blood flow,and improve nerve function in patients with severe craniocerebral injury.

Objective   To investigate the effect of modified breathing exercises combined with aromatherapy in radiofrequency ablation in patients with atrial fibrillation.Methods   A total of 82 patients with atrial fibrillation undergoing radiofrequency ablation treated in Tianjin Chest Hospital from August 2022 to August 2024 were selected and divided into two groups according to random number table,with 41 cases in each group.The control group was given routine nursing after surgery,and the experimental group was given modified breathing exercises combined with aromatherapy intervention after surgery.The cardiopulmonary function,nausea and vomiting degree and adverse mood of the two groups were compared.Results   After intervention,the values of left ventricular ejection fraction(LVEF),forced vital capacity(FVC) and forced expiratory volume at the first second(FEV1) of the experimental group were(57.59±3.64)%,(3.68±0.41)L and(2.94±0.39)L respectively,higher than the control group(55.51±4.22)%,(3.38±0.39)L,(2.52±0.39) L(P<0.05);The scores of nausea,vomiting,dry heaves of the experimental group were(4.05±0.97),(1.88±0.60),(1.59±0.87) respectively,lower than the control group(4.61±1.02),(2.54±0.87),(2.02±0.79),P<0.05;The scores of anxiety and depression in the experimental group were (36.49±3.49) and(32.98±2.39)respectively,lower than those in the control group(38.15±2.92) and(34.54±2.80),P<0.05.Conclusion   Modified breathing exercises combined with aromatherapy can improve the cardiopulmonary function of patients with atrial fibrillation after radiofrequency ablation,reduce the degree of nausea and vomiting,and relieve their bad mood.

Objective   To investigate the effect of continuous nursing with traditional Chinese medicine characteristics on the postoperative rehabilitation of patients with lumbar disc herniation(LDH) undergoing percutaneous endoscopic lumbar discectomy(PELD).Methods   70 patients with LDH after PELD surgery admitted to the Spinal Minimally Invasive Orthopedics Department of Gansu Provincial Hospital of Traditional Chinese Medicine were divided into two groups using the envelope method.After exclusion,28 patients in the control group received conventional treatment,while 31 patients in the observation group received continuous nursing with traditional Chinese medicine characteristics on the basis of the control group.They were followed up continuously until 6 months after surgery.The recovery of pain,function,and quality of life of the two groups of patients before discharge and after surgery,as well as the nursing satisfaction at the last follow-up,were observed.Results   6 months after surgery,compared with the visual analogue scale(VAS) score(1.50±0.64),the lumbar Oswestry disability index(ODI)(12.96±2.25)%,and the short-from-36 health survey(SF-36) score(54.42±3.17) in the control group,VAS score (0.68±0.54),ODI score(9.81±1.56)% and SF-36 score(63.13±4.01) in the observation group were significantly increased,and the differences were statistically significant(P<0.05).There was no difference of statistical significance in nursing satisfaction between the two groups(P>0.05).Conclusion   Continuous nursing intervention with traditional Chinese medicine characteristics can significantly improve the recovery effect of postoperative pain,function and quality of life in LDH patients after PELD,and has a certain degree of patient recognition.

Objective   To observe the clinical efficacy of Gancao Xiexin Decoction combined with compound chlorhexidine gargle in the treatment of recurrent oral ulcer(ROU) with the intermingled cold and heat syndrome.Methods   Seventy-two ROU patients with the intermingled cold and heat syndrome who visited the traditional Chinese medicine clinic of Beijing Chemical Occupational Disease Prevention and Control Institute and Aerospace Center Hospital from January 2022 to July 2024 were screened.They were randomly divided into the observation group and the control group using the random number table,with 36 cases in each group.Patients in the control group were treated with compound chlorhexidine gargle,and those in the observation group were orally administered Gancao Xiexin Decoction combined with compound chlorhexidine gargle.The medication was continued for 1 week.The visual analogue scale(VAS) score of the pain and the integral of symptoms and signs(comprehensively determined from the size of the ulcer surface，exudation,congestion,edema,ulcer pain,burning sensation,dry mouth and thirst,dry stool and constipation,etc.) before and after treatment in both groups were compared.The clinical effect after the treatment was evaluated through the integral of symptoms and signs before and after treatment,and the recurrence situation was followed up by telephone contact 3 months later.Results   After 1 week of treatment,the VAS score and the integral of symptoms and signs in the observation group were significantly lower than those of the control group(P<0.05).Through the Mann-Whitney U test,the total effective rate of the observation group was significantly higher than that of the control group(97.2% VS 94.4%,P<0.001).The recurrence rate was followed up by telephone 3 months later.Through the chi-square test,the recurrence rate of the observation group was significantly lower than that of the control group(17.1% VS 44.1%,P=0.015).Conclusion   Gancao Xiexin Decoction combined with compound chlorhexidine gargle has a better effect on the treatment of ROU with the intermingled cold and heat syndrome,especially in improving symptoms and signs,and it can reduce the recurrence rate.

Primary osteoporosis is a systemic skeletal disease characterized by low bone density and destruction of bone microstructure,which significantly increases the risk of fractures.With the acceleration of global aging,the incidence of primary osteoporosis has been annually elevated,causing serious impacts on the quality of life.In recent years,non-pharmacological interventions have been gradually concerned.The exercise training is considered as an effective treatment method.This review aims to summarize the research progress of exercise training in the treatment of primary osteoporosis,focusing on the effects of different types,intensities,and frequencies of exercise on bone density,bone quality,and functional ability.By analyzing recent clinical studies and experimental data,this article revealed the potential of exercise training in improving the quality of life,enhancing bone strength,and reducing the risk of fractures,providing important references for subsequent clinical practice and research.Although previous studies have shown a positive impact of exercise training on primary osteoporosis,further exploration is needed to find the optimal exercise intervention scheme and long-term effects,in order to provide more personalized treatment strategies for primary osteoporosis.

Immune deficiency is the most important clinical manifestation of AIDS patients,which is characterized by sustained damage to immune cells in the body,resulting in immune imbalance and immune cell exhaustion,leading to a variety of serious complications and eventually death.TCM takes syndrome differentiation and treatment as the guiding ideology,and AIDS treatment takes supporting righteousness and dispelling evil in the body as the main treatment methods,which has obtained good results in clinical practice.A number of previous studies have shown that after the TCM supplementing Qi and enforcing strength treatment of AIDS,the immune function of patients has been improved,among which the number of CD4+T cells has increased most significantly,and the functions of T cells,NK cells and B cells have improved to a certain extent,regulating the balance between immune factors,thereby improving the quality of life of patients and prolonging their life span.However,there is still a lack of in-depth basic research support.Therefore,on the basis of literature review,this paper summarizes the understanding of the etiology and pathogenesis of AIDS in Chinese medicine in recent years,and discusses the therapeutic research on improving the immune function of patients with Chinese medicine,aiming to provide reference for the later treatment of AIDS.

Stroke is the main cause of disability globally,and spasticity is a common and serious complication that seriously affects the daily life and self-care ability,and reduces the quality of life.Repetitive peripheral magnetic stimulation(rPMS) is a non-invasive rehabilitation method,showing characteristic of safety,low cost,and efficacy.It has been gradually applied to the treatment of spasticity after stroke.rPMS acts on peripheral nerves and muscles through specific magnetic fields,affecting the electrophysiological characteristics of nerve cells,thereby regulating muscle excitability,promoting local blood circulation,and achieving the goal of reducing spasms and improving motor function.This review systematically reviewed the research progress of rPMS in the treatment of spasticity after stroke,and analyzed its treatment mechanism,effect evaluation,and clinical application,aiming to provide more references for its clinical application and benefits to rehabilitation.

As the global population continues to age,sarcopenia becomes a widely concerned condition that significantly affects the ability to live independently and quality of life in the elderly.Sarcopenia is not only associated with the loss of muscle mass and strength,but also closely linked to geriatric syndromes,which increases the risk of frailty,falls,fractures,and various chronic diseases,such as metabolic syndrome,cardiovascular disease,and osteoporosis.This review explored the pathogenesis of sarcopenia and the key signaling pathways involved in its development and progression,including the AMPK,mTOR,Akt/mTOR,Myostatin/SMAD,Wnt/β-catenin,and SIRT1 signaling pathways.A deeper understanding of these pathways can aid in the development of effective treatments for sarcopenia.Proper assessment and monitoring of sarcopenia progression,combined with interventions targeting these pathways,lifestyle adjustments,nutritional support,and social assistance,can enhance the independence and reduce the reliance on healthcare systems of sarcopenia patients.Future research will continue to focus on the regulatory mechanisms of these pathways to offer individualized treatment,improving the health and quality of life of the elderly.

Physiological functions gradually decline with aging,leading to a significantly increased risk of multiple chronic diseases like hypertension,diabetes,cardiovascular diseases,and cancer.Advances in medical diagnostics and comprehensive treatments have made multimorbidity increasingly common among older adults,with polypharmacy becoming a prevalent approach to manage them.However,polypharmacy is associated with potential risks,including potentially inappropriate medication(PIM) and adverse drug events(ADEs),which are particularly pronounced in frail patients.Frailty is an age-related syndrome characterized by reduced physiological reserves and diminished adaptability to external stressors,serving as an independent risk factor for falls,hospitalization,and mortality.Frailty not only affects drug metabolism and elimination,but also increases the complexity of drug interactions,thereby exacerbating the adverse outcomes associated with polypharmacy.Additionally,polypharmacy may further aggravate frailty through medication-related side effects and negative impacts on the functional status.We aimed to explore the bidirectional relationship of frailty with  polypharmacy,and PIM in older adults.Through analyzing how these factors interact and collectively influence health outcomes,and reviewing current research progress,we provided a theoretical foundation for optimizing medication management in older patients.

Objective   To investigate the changes in serum lipoprotein-associated phospholipase A2(Lp-PLA2) and S100 calcium-binding protein beta(S100β) levels in patients with acute cerebral infarction(ACI),and to analyze their predictive value in the outcome.Methods   A total of 120 ACI patients admitted to the Third People's Hospital of Anyang City from May 2022 to May 2024 were retrospectively analyzed.All of them received thrombolytic therapy.Based on the disease outcomes at 3 months of treatment,68 patients were categorized into the good outcome group and 52 patients into the poor outcome group.The clinical data, and serum Lp-PLA2 and S100β levels before and 1 month after treatment were compared.Multivariate logistic regression analysis was used to analyze the influencing factors for the outcome of ACI.The correlation of serum Lp-PLA2 and S100β levels with the outcome of ACI was analyzed by partial correlation analysis.The predictive value of serum Lp-PLA2 and S100β in the 1-month outcome of ACI was evaluated.The independent and interactive effects of Lp-PLA2 and S100β on the outcome of ACI were analyzed.Results   Serum Lp-PLA2 and S100β at 1 month of treatment in the poor outcome group were significantly higher than those of the good outcome group(P<0.05).Hypertension,atrial fibrillation history,disease severity,and serum levels of high-sensitivity C-reactive protein(hs-CRP),Lp-PLA2,and S100β were independent risk factors for the outcome of ACI(P<0.05).After excluding other confounding factors like hypertension,atrial fibrillation history,disease severity,and serum hs-CRP levels,serum Lp-PLA2 and S100β levels were still significantly positively correlated with the poor disease outcomes(P<0.001).The area under the curve(AUC) of the combined prediction of serum Lp-PLA2 and S100β levels in the prognosis of ACI was significantly greater than that of a single indicator(P<0.05).Model 1(adjusting for confounding factors),model 2(adjusting for hypertension,atrial fibrillation history,and disease severity),and model 3(adjusting for hypertension,atrial fibrillation history,disease severity,and serum hs-CRP level) were established.In model 1,2,and 3,the risk of poor disease outcomes in ACI patients with high Lp-PLA2 expression was 2.305 times,2.597 times,and 2.944 times higher than that in patients with low expression,respectively.The risk of poor disease outcomes in CI patients with high S100β expression was 2.195 times,2.522 times,and 2.747 times higher than that in patients with low expression,respectively.Furthermore,interaction analysis showed that Lp-PLA2 and S100β had a synergistic effect on disease outcomes.Conclusion   Serum Lp-PLA2 and S100β increase in ACI patients with a poor prognosis,serving as independent risk factors for disease progression.At the same time,Lp-PLA2 and S100β have a synergistic effect on disease progression,and a combined detection of their levels has certain predictive value for disease progression.

Objective   To explore the influencing factors of sedentary behavior in patients underwent percutaneous coronary intervention(PCI),and to construct and verify the decision tree prediction model.Methods   A total of 176 patients who underwent PCI from May 2022 to November 2023 were retrospectively selected as the study subjects.They were divided into sedentary behavior group(n=56) and non-sedentary behavior group(n=120) according to whether sedentary behavior occurred after PCI.The related factors affecting sedentary behavior after PCI were analyzed,and the decision tree prediction model was constructed.Another 75 patients who underwent PCI from December 2023 to June 2024 were selected as the validation group,and the receiver operating characteristic(ROC) curve was used to evaluate the predictive efficacy of the model.Results   Of the 176 patients underwent PCI,56(31.82%) had sedentary behavior and 120(68.18%) had no sedentary behavior.The multivariate Logistic regression analysis showed married status,family monthly income of 3 000 yuan,number of 3 kinds of chronic diseases,non-exercise status,grade Ⅱ New York Heart Association(NYHA) cardiac function classification and high level of D-dimer were independent risk factors for sedentary behavior after PCI,and low level of the social support rating scale(SSRS) score was its protective factor(P<0.05).The proportion of nodes with sedentary behavior after PCI was used to represent the risk of sedentary behavior after PCI in this group of people.Six types of high-risk groups were screened out,including normal-level D-dimer + family monthly income of ≤3 000 yuan(71.40% of the node composition),high-level D-dimer+ normal-level SSRS score(44.00% of the nodes),high-level D-dimer+ normal-level SSRS score+<3 kinds of chronic diseases(80.00% of the node composition),high-level D-dimer+ low-level SSRS score + married status(30.00% of the nodes),high-level D-dimer+ low-level SSRS score+ unmarried status(40.00% of the nodes),and high-levelD-dimer+ low-level SSRS score+<3 kinds of chronic diseases(80.00% of the node composition).In the ROC curve,the area under the curve(AUC) of the training set was 0.912(95%CI:0.860,0.963 ),with the sensitivity of 80.40%,and the specificity of 92.50%.The AUC of the validation set was 0.860(95%CI：0.749,0.970),with the sensitivity of 69.20%,and the specificity of 91.90%,which proved that the model had a good fit. Conclusion   The sedentary behavior of patients underwent PCI is affected by many factors.The decision tree model constructed by related factors has a good prediction of the risk of sedentary behavior after PCI.

Objective   To explore the application effect of an integrated treatment for patients with severe multi-trauma in the trauma center.Methods A retrospective analysis was conducted on the clinical data of patients with severe multi-injuries admitted to Longhua District Central Hospital in Shenzhen,Guangdong Province.A total of 90 patients who received routine emergency treatment from June 2021 to December 2022 were selected as the control group,and 90 patients who received an integrated trauma center treatment from January 2023 to June 2024 were selected as the study group.The success rate of rescue,first aid time,prognosis and adverse events were compared.Results   The success rate of rescue in the study group was significantly higher than that of the control group(96.67% VS 88.89%,χ2= 4.063,P=0.044).The time of admission,the time of consultation doctors in place,the time of stay in the rescue room,the time from admission to completion of imaging examination,the time from admission to emergency operation in the study group were significantly lower than those of the control group(P<0.05).Two days after admission,the scores of trauma severity,and the acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) in the two groups were significantly reduced than the baseline before admission,which were significantly lower in the study group than the control group(P<0.05).The incidence of adverse events in the study group was significantly lower than the control group(P<0.05).Conclusion The integrated treatment mode of trauma center can effectively improve the first aid efficiency of patients with severe multi-trauma,significantly improve the success rate of rescue,improve the prognosis,and reduce the risk of adverse events,which provides a new choice for the first aid mode of patients with multi-trauma.

Objective To explore the clinical application of the novel UBE technique combined with modified minimally invasive instrumentation for thoracolumbar spinal tuberculosis (STB). Methods Prospective selected 84 patients diagnosed with thoracolumbar spinal tuberculosis in our hospital from January 2024 to October 2024, and according to random number table method which were divided into control group and observation group, each group of 42 people. The control group used traditional posterior lesion removal and fusion fixation, and the observation group performed minimally invasive lesion removal and fusion fixation with the new UBE technique + modified nailing method. Perioperative indicators, postoperative spinal function, spinal pain, blood loss (ESR), Oswestry spinal dysfunction index (ODI) and complications were compared. Results Perioperative indexes IBL, IBTV, OT and LOS were lower than those of the control groups and were significant (all P <0.05). There was no statistical difference in JOA function JOA score, VAS score, ESR level, and ODI between the two groups (all P> 0.05); after treatment, the observation group was higher than the control group, and the VAS score, ESR level and ODI were lower than the control group, with a statistically significant difference (all P <0.05). The overall incidence of complications after treatment in the observation group was lower than that in the control group, and the difference was not significant (P >0.05). Conclusion The new UBE technology combined with improved minimally invasive internal fixation for the treatment of thoracolumbar spinal tuberculosis can significantly reduce the surgical trauma, accelerate the postoperative recovery of patients, relieve the postoperative spinal pain, have a positive effect on the recovery of postoperative spinal function, and has good safety, which is worthy of further promotion and application in clinical practice.

Objective   To investigate the current situation of lower extremity deep vein thrombosis(LEDVT) in patients with mechanical ventilation in the intensive care unit(ICU),and to analyze the risk factors.Methods   A total of 350 patients who received mechanical ventilation in the general ICU of the Affiliated Hospital of North China University of Science and Technology from August 2023 to February 2024 were selected by convenience sampling method.A self-designed scale for assessing risk factors of LEDVT in ICU patients with mechanical ventilation was used to survey participants.The univariate analysis and Logistic regression analysis were used to screen the risk factors for LEDVT in ICU patients with mechanical ventilation.Results   The incidence of LEDVT in ICU patients with mechanical ventilation was 22%.Univariate analysis showed that age≥70 years,history of central venous catheterization,blood transfusion,use of sedatives,duration of mechanical ventilation≥3 days,addition of positive end-expiratory pressure(PEEP),D-dimer≥450 μg/L,plasma fibrinogen,and bedside hemofiltration were significantly associated with LEDVT in ICU patients with mechanical ventilation(P<0.05).The results of multivariate results showed that the age≥70 years(OR=2.619,95% CI:1.372,5.001,P=0.004),the duration of mechanical ventilation≥3 days(OR=11.255,95% CI:3.206,39.514,P<0.001),the addition of PEEP(OR=3.227,95% CI:1.488,7.001,P=0.010),and D-dimer≥450 µg/L(OR=2.925,95% CI:1.299,6.589,P=0.01),plasma fibrinogen(OR=2.676,95% CI:1.347,5.315,P=0.005),and blood transfusion history(OR=1.960,95% CI:1.056,3.639,P=0.033) were independent risk factors for LEDVT in ICU patients with mechanical ventilation.Conclusion   Early screening for LEDVT should be carried out for ICU patients with mechanical ventilation.Age≥70 years,mechanical ventilation time≥3 days,addition of PEEP,D-dimer ≥450 μg/L,blood transfusion,and plasma fibrinogen are the key groups for screening of LEDVT in ICU patients with mechanical ventilation.

Objective   To obtain the knowledge-attitude-belief-practice(KABP) data of tuberculosis(TB)in people from some league cities in Inner Mongolia Autonomous Region in 2023,and to explore the relationship between different factors and the awareness rate of eight TB-related prevention and control knowledge in the questionnaire.Methods   A total of 2 346 people from 6 league cities in Inner Mongolia Autonomous Region were selected using a modified questionnaire with multi-stage stratified random sampling.Difference in the awareness rate of TB-related prevention and control information under different factors was compared.Results   In 2023,the total awareness rate of TB-related knowledge was 43.17%.The results of univariate analysis showed that the residence,nationality,marital status,educational level,occupational status and main medical treatment were the factors affecting the knowledge of TB prevention and control(P<0.05).Logistic regression results showed that the residence,nationality,educational level and occupational status were the factors influencing the awareness rate of TB-related prevention and control knowledge(P<0.05).Conclusion   At present,the awareness rate of TB-related prevention and control knowledge in Inner Mongolia Autonomous Region is low,and the attitude of people towards TB and TB-related prevention and control knowledge is negative.The promotion and strengthening of TB-related knowledge using appropriate methods for different groups of people and guiding people to make correct behaviors in the face of TB will help accelerate the realization of the great strategy of eliminating TB.

Objective   To explore and analyze the correlation of health literacy,health behavior and quality of life with the recurrence of gallstones after lithotomy.Methods   A total of 152 patients who underwent lithotomy in Nanchang Xinjian District People's Hospital from April 2020 to April 2024 were selected and divided into the recurrence group (48 cases) and the non-recurrence group (104 cases) according to the recurrence. The general data,the health literacy questionnaire of Chinese citizens and the quality of life scale scores were collected to analyze influencing factors for the recurrence of gallstones after lithotomy.Correlation analysis was made between the scores of health literacy,and quality of life with gallstone recurrence.Results   Logistic regression analysis showed that education level(OR=12.443,95% CI:2.756,56.176,P=0.001),health literacy(OR=0.691,95% CI:0.566,0.842,P<0.001),and quality of life(OR=0.618,95% CI:0.505,0.757,P<0.001) were related factors for the recurrence of gallstones after lithotomy(all P<0.05).Linear correlation analysis showed that the health literacy,health behavior,and quality of life were negatively correlated with gallstone recurrence after lithotomy(all P<0.01).Conclusion   The improvement of health literacy,health behavior and quality of life can significantly reduce the recurrence rate of gallstones in patients who have undergone lithotomy.