Objective To investigate the molecular mechanism by which repeated low-level red light(RLRL) suppresses form-deprivation myopia(FDM) and determine whether it acts through the epidermal growth factor receptor(EGFR) pathway to regulate adenylyl cyclase(AC)/cyclic adenosine monophosphate(cAMP) signaling.Methods Forty-eight 3-week-old guinea pigs were ear-tagged and randomly assigned,using a random number table,to six groups: normal control(NC),RLRL,RLRL+EGFR knockdown(RLRL+EGFR-KD),RLRL+AC knockdown (RLRL+AC-KD),RLRL+EGFR knockdown+AC overexpression(RLRL+EGFR-KD+AC-OE),and RLRL+adeno-associated virus empty-vector control(RLRL+AAV-Ctrl).Except for the NC group,a right-eye FDM model was established in all animals,followed by RLRL treatment.In selected groups,intravitreal AAV injection was performed in advance to regulate EGFR or AC expression.Axial length(AL),refractive error(RE),and the mRNA and protein levels of EGF,EGFR,and AC in ocular tissues were measured.Results After 4 weeks of modeling,the covered eyes in the RLRL group showed a smaller reduction in hyperopic shift and slower AL elongation(both P<0.05).The myopia-suppressive effect was significantly weaker in the RLRL+EGFR-KD and RLRL+AC-KD groups than in the RLRL group(both P<0.05),and no improvement was observed in the RLRL+EGFR-KD+AC-OE group.In ocular tissues from the RLRL group,the mRNA and protein levels of EGF,EGFR,and AC were all higher than those in the NC group,and cAMP levels changed in a pathway-dependent manner.Conclusion RLRL can effectively suppress the progression of FDM in guinea pigs.Its mechanism may involve regulation of EGF/EGFR signaling in the retina and sclera,activation of the downstream AC/cAMP pathway,and action through the retina-choroid-sclera cascade.EGFR is a key upstream node in this pathway,and its integrity is essential for the AC/cAMP-mediated anti-myopia effect.
Objective To understand the current research status,hotspots,and development trends in the field of stroke based on the visualization analysis of rehabilitation robots in this field in China conducted by CiteSpace.Methods The relevant literature on rehabilitation robots in the field of stroke from the CNKI,Wanfang Database,and VIP Chinese information network from January 2006 to June 2025 was selected.CiteSpace 6.3.3 was used to conduct metrological mapping and analysis of the number of publications,authors,keyword co-occurrence,clustering,emergence,and timeline.Results The annual number of publications in this field has been increasing year by year.Among them,Fu Jianming has the largest number of publications (19 articles),and the frequently used keywords for rehabilitation robots mainly include 9 clusters such as balance function,rehabilitation,and human-computer interaction.Conclusion Rehabilitation robots are a new force in the field of stroke medical treatment nowadays,focusing on the entire process of rehabilitation therapy.This study has found that the current research hotspots are concentrated on three core areas: gait function,balance function,and upper limb function.In the future,we will further conduct in-depth research on the application of rehabilitation robots in the field of stroke,strengthen multidisciplinary cooperation and interdisciplinary research,and jointly promote the comprehensive development of the stroke field.
Objective To investigate the value of combined testing of the gastric function four indexes and tumor markers in the differential diagnosis of gastric cancer lesions among patients with gastric diseases in the Department of Gastroenterology,and to construct a risk prediction model for gastric cancer lesions,thereby providing a clinical basis for early diagnosis and disease monitoring of gastric cancer in patients with gastric diseases.Methods A total of 90 patients with gastric diseases admitted to Pengze People's Hospital from January 2024 to June 2025 were enrolled in the gastric disease group.According to Helicobacter pylori(Hp) infection status and gastroscopic biopsy pathology results,the gastric disease group was divided into a gastric cancer group (24 cases),a precancerous lesion group (34 cases),and a non-atrophic gastritis group (32 cases).In addition,50 healthy individuals undergoing physical examination at the same hospital during the same period were selected as the healthy control group.Baseline data were collected.The gastric disease group was first divided into a gastric cancer group and a non-gastric cancer group (precancerous lesion group+non-atrophic gastritis group) for univariate analysis of gastric cancer lesions.Variables showing statistical significance in the univariate analysis were then entered into multivariate Logistic regression to identify risk factors for gastric cancer lesions.A risk prediction model was constructed,and its predictive performance was evaluated using receiver operating characteristic(ROC) curves.Results The gastric cancer group had significantly lower pepsinogen Ⅰ(PGⅠ) levels than the precancerous lesion group,non-atrophic gastritis group,and healthy control group,whereas pepsinogen Ⅱ(PGⅡ),gastrin-17(G-17),Helicobacter pylori immunoglobulin G antibody(Hp-IgG),carcinoembryonic antigen(CEA),and carbohydrate antigen 125(CA125) were significantly higher than those in the precancerous lesion group,non-atrophic gastritis group,and healthy control group(P<0.05).Multivariate Logistic regression analysis,with the gastric cancer group and non-gastric cancer group within the gastric disease cohort as the study subjects,confirmed that decreased PGⅠ,increased PGⅡ,increased G-17,increased Hp-IgG,increased CEA,and increased CA125 were independent risk factors for gastric cancer lesions(P<0.05).A prediction model was constructed using these risk factors as predictors.The ROC curve showed that the model had an area under the curve(AUC) of 0.846,standard error of 0.041,95%CI(0.764-0.946),sensitivity of 0.857,and specificity of 0.866.Conclusion Combined testing of the gastric function four indexes and tumor markers can effectively reflect the degree of gastric mucosal lesions.Decreased PGⅠ,increased PGⅡ,increased G-17,increased Hp-IgG,increased CEA,and increased CA125 are independent risk factors for gastric cancer lesions.The risk prediction model constructed on the basis of these indicators demonstrates good predictive performance in the differential diagnosis of gastric cancer among patients with gastric diseases in the Department of Gastroenterology and may serve as an effective tool for early diagnosis and risk assessment of gastric cancer in these patients.
Objective To construct a knowledge map of the field of pulmonary rehabilitation for stroke using bibliometric methods,and to reveal the research status,knowledge structure,hot topics,and evolutionary trends in this field.Methods Relevant literature published in the China National Knowledge Infrastructure(CNKI) database and Web of Science(WOS) from database inception to October 31,2024 was retrieved.CiteSpace 6.2.R4 was used for quantitative and visual analysis.Results A total of 313 Chinese-language articles and 88 English-language articles were included.The analysis showed that the international collaboration network in this field was sparse,while domestic collaboration exhibited an unbalanced pattern characterized by "small clusters and wide dispersion".Research hotspots included exercise tolerance,dysphagia,diaphragmatic function,and pulmonary infection,which together formed the basic framework of current research.Temporal evolution analysis indicated that the research focus has shifted from early prevention and control of pulmonary infection,through the deepening study of swallowing and respiratory function rehabilitation,toward frontier areas such as precise diaphragmatic function intervention and technology-integrated rehabilitation.Conclusion Bibliometric visual analysis can clearly delineate the knowledge framework and evolutionary trajectory of pulmonary rehabilitation for stroke.Future research should focus on breaking institutional barriers,promoting interdisciplinary collaboration,and fully leveraging information technology to explore new models of precision and intelligent pulmonary rehabilitation
Objective To investigate the current status of frailty and its multilevel influencing factors among elderly patients with hypertension residing in nursing institutions using a health ecology model,thus providing a theoretical basis for developing targeted intervention strategies.Methods This was a cross-sectional study involving 267 elderly patients with hypertension from nine nursing institutions in Taizhou City from March to August 2025 through convenience sampling.Patients were surveyed using a general information questionnaire and the fatigue,resistance,ambulation,illnesses,and loss of weight(FRAIL) scale to assess frailty status.Hierarchical linear regression models were applied to analyze the influencing factors for frailty.Results A total of 267 participants were included,with a frailty prevalence of 42.70%(114/267) and a mean total frailty score of (2.45±0.85).Hierarchical regression analysis showed that the model's goodness of fit (R²) increased from 28.3% to 66.7% with the stepwise introduction of variable layers.Types of chronic diseases(β=0.416,P<0.001),overweight(β=0.212,P=0.008),and self-rated health status(β=0.476,P<0.001) were identified as risk factors for frailty.In contrast,exercise frequency(β=-0.123,P=0.004),urban household registration(β=-0.331,P<0.001),higher personal monthly income(β=-0.143,P=0.003),and higher educational attainment(β=-0.385,P<0.001) served as protective factors.Conclusion The prevalence of frailty among elderly patients with hypertension residing in nursing institutions in Taizhou is relatively high.Its occurrence is jointly influenced by multiple levels of factors,including individual characteristics,behavioral attributes,interpersonal networks,and living and working conditions.An integrated intervention program should be developed based on the health ecology model,centering on multi-dimensional strategies,including weight and comorbidity management,promotion of regular physical activity and medication adherence,optimization of the care environment,and enhancement of health literacy,thus effectively preventing and controlling frailty.
Objective To investigate the current research status of the application of traditional Chinese medicine (TCM) nursing appropriate technologies in cardiovascular diseases,analyze the research hotspots and evolution trends in this field,and provide a scientific basis for future application of TCM nursing appropriate technologies in patients with cardiovascular diseases.Methods Literature related to the application of TCM nursing appropriate technologies in cardiovascular diseases,published between January 1,1995 and February 22,2025,was retrieved from the China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP,China Biology Medicine disc(CBM),Web of Science Core Collection,and PubMed.CiteSpace 6.3.R1 (64-bit) was used to conduct visual analysis of the included literature.Results After deduplication,655 Chinese-language articles and 193 English-language articles were included.Because the number of English-language articles was relatively small,only the Chinese literature was subjected to visual analysis.From 2009 to 2024,the number of publications on the application of TCM nursing appropriate technologies in cardiovascular diseases showed an upward trend.Based on keyword co-occurrence network node centrality and burstiness analysis,the main research hotspots were coronary heart disease,acupoint application,angina pectoris,auricular acupressure,and tuina massage.The research frontiers were mainly focused on insomnia,sleep quality,stable angina pectoris,and cardiac function.Conclusion The application of TCM nursing appropriate technologies in cardiovascular diseases is becoming increasingly diversified.Future research should focus on developing standardized integrated Chinese and Western medicine intervention protocols,conducting high-quality studies,and deepening mechanistic research.Meanwhile,an evaluation system for the effectiveness of TCM nursing in cardiovascular specialties should be established to promote the inclusion of TCM nursing protocols in international cardiovascular disease prevention and treatment guidelines and provide a China-based solution for global cardiovascular disease management.
Objective To investigate the intervention effect of comprehensive management on childhood and adolescent obesity in Suqian.Methods From June to November 2025,a total of 2 057 children and adolescents across all age groups were enrolled from the entire Jiangsu Suqian Economic Development Zone,including both rural and urban areas,based on health examination data and relevant information.A prospective randomized controlled trial was conducted,and 124 obese children and adolescents were ultimately identified.They were randomly assigned using a random number table to a control group(n=62) and a study group(n=62).The control group received routine child health care intervention,while the study group received digital therapy in addition to routine intervention.Physical indicators,laboratory indicators,diet and exercise behavior scores,and mental health scores were compared between the two groups.Results The study group had lower body mass,waist circumference,hip circumference,waist-to-hip ratio,and body fat percentage than the control group(P<0.05).After intervention,the study group had lower levels of total cholesterol(TC)([4.17±0.49]mmol/L VS [4.41±0.51]mmol/L),triglyceride(TG)([1.55±0.29]mmol/L VS [1.67±0.33]mmol/L),low-density lipoprotein cholesterol(LDL-C)([2.58±0.43]mmol/L VS [2.78±0.46]mmol/L),fasting plasma glucose(FPG)([5.03±0.45]mmol/L VS [5.21±0.48]mmol/L),and hemoglobin A1c(HbA1c)([5.59±0.31]% VS [5.72±0.28]%) than the control group,while high-density lipoprotein cholesterol(HDL-C) was higher than that of the control group ([1.21±0.22]mmol/L VS [1.10±0.19]mmol/L),P<0.05.After intervention,the total diet and exercise behavior score in the study group (16.11±2.76) was higher than that in the control group (14.97±2.04),P<0.05.After intervention,the total PedsQL score in the study group (75.64±6.63) was higher than that in the control group (72.55±6.97),P<0.05.Conclusion A comprehensive intervention combined with digital therapy can improve physical indicators and metabolic parameters in obese children and adolescents,enhance mental health,and ultimately promote the development of healthy dietary and behavioral habits.This model has practical value.However,this study had a small sample size,a short intervention period,and subjective bias in behavior scoring,and could not fully control for factors such as genetics and family environment.Further studies with larger sample sizes and longer follow-up periods are needed to verify the stability of the findings.
bjective To explore the efficient promotion paths of traditional Chinese medical exercises in the context of "Healthy China" and the digital age.Methods The "Baduanjin" digital promotion project led by the Taihang Traditional Chinese Medicine Hospital served as a practical example.By establishing a professional exercise team,a promotion model combining "inside and outside the hospital" and "online and offline" interaction was constructed.Moreover,various technical means such as online live streaming,short videos,AI action recognition,and multilingual translation were comprehensively utilized to conduct precise and interactive promotion for various groups including patients with chronic diseases,teenagers,young and middle-aged people,and international friends.Results The project activities involved approximately 30 000 person-time.The rate of key health indicators reaching the standard for chronic disease patients increased by 15%,and the AI technology reduced the deviation rate of movements by 40%.A replicable three-dimensional promotion model of "digital+culture+health" was established.Conclusion Digital dissemination serves as an effective path to overcome the bottleneck in the inheritance and promotion of traditional Chinese medicine(TCM) exercises.By technology empowerment,model innovation,and ecosystem co-construction,it can significantly enhance dissemination efficiency,health intervention effectiveness,and cultural influence.This approach holds significant reference value for promoting the high-quality development of the TCM industry.
Objective To explore the impact of a 30-day exercise therapy prescription,formulated based on individualized assessment,on the core muscle strength and functional movement patterns of aircrew convalescent personnel.Methods A total of 110 aircrew recuperation personnel from a certain center were selected and divided into a control group and a study group according to the random number table,with 55 cases in each group.The control group received the routine recuperation prescription,while the study group implemented an individualized exercise recuperation prescription based on the control group.Before and after the intervention,the Functional Movement Screen (FMS) scoring system was used to assess the overall movement patterns and potential injury risks for both groups of patients,and the peak static isometric contractions of the core muscles of the waist in six directions of the anterior-posterior flexion and extension,left-right rotation,and left-right lateral bending were measured.Results After the intervention,the anterior flexion muscle strength of the study group was (304.87±34.39)N,the posterior extension muscle strength was (722.89±67.89)N,the left flexion muscle strength was (266.16±39.17)N,the right flexion muscle strength was (250.55±29.89)N,the left rotation muscle strength was (235.51±29.23)N,and the right rotation muscle strength was (226.25±39.08)N.The total score of FMS was (19.07±1.07)points.The anterior flexion muscle strength of the control group was (289.55±31.58)N,the posterior extension muscle strength was (678.09±66.80)N,the left flexion muscle strength was (250.44±35.23)N,the right flexion muscle strength was (238.76±28.80)N,the left rotation muscle strength was (223.96±26.90)N,and the right rotation muscle strength was (211.98±34.24)N.The total score of FMS was (17.24±1.57)points.Comparison between the groups showed the study group had higher scores than the control group,and the differences were statistically significant(P<0.05).Conclusion Individualized exercise therapy prescriptions can effectively improve the functional movement screening scores and core muscle strength of aircrew convalescent personnel,providing a basis for their application and promotion in aviation medical support and health promotion.
Objective To investigate the effects of different anti-osteoporosis drugs on bone mineral density(BMD),alkaline phosphatase(ALP),25-hydroxyvitamin D[25-(OH)D],procollagen type Ⅰ C-terminal propeptide(PICP),β-C-terminal telopeptide of type Ⅰ collagen(β-CTX),osteocalcin(OC),and other bone-derived collagen metabolic turnover markers in patients with osteoporosis receiving maintenance hemodialysis,so as to provide more clinical data for the treatment of maintenance hemodialysis patients complicated with osteoporosis and thereby improve quality of life and prognosis.Methods A total of 300 maintenance hemodialysis patients admitted to the Hemodialysis Center of the People's Hospital of Tongnan District,Chongqing City,from May 1,2024 to May 1,2025 were selected.General patient information and dialysis-related data were collected,and markers of bone-derived collagen metabolic turnover,including 25-(OH)D,ALP,calcium(Ca),phosphate(P),intact parathyroid hormone(iPTH),PICP,β-CTX,OC,as well as BMD,were measured.Maintenance hemodialysis patients diagnosed with osteoporosis after exclusion of adynamic bone disease were randomly assigned to group A,group B,and group C using a random number table.On the basis of routine dialysis and control of underlying diseases and complications,group A received conventional treatment with calcium supplementation and vitamin D;group B received oral risedronate on the basis of treatment in group A;and group C received denosumab on the basis of treatment in group A.BMD,25-(OH)D,ALP,Ca,P,iPTH,PICP,β-CTX,OC,and adverse reactions were observed before treatment and after 6 months of treatment in the three groups.Results Before treatment,there were no statistically significant differences among the three groups in serum general characteristics,blood Ca,P,BMD,ALP,25-(OH)D,PICP,β-CTX,or OC(P>0.05).After 6 months of treatment,BMD in groups C and B increased significantly from baseline,and the improvement in BMD in group C was greater than that in group B(P<0.05).ALP,25-(OH)D,PICP,β-CTX,and OC were significantly lower than those before treatment(P<0.05),whereas iPTH showed no significant change before and after treatment in the three groups (P>0.05).Conclusion Risedronate and denosumab,in combination with calcium and vitamin D supplementation,can significantly improve BMD and osteoporosis status in patients receiving maintenance hemodialysis,thereby reducing fracture risk,improving prognosis,and enhancing quality of life.
Objective To investigate the effects of comprehensive visual function rehabilitation training on ocular surface symptoms,visual fatigue,and work efficiency in patients with dry eye disease and video display terminal(VDT) syndrome.Methods A total of 112 patients with dry eye disease and VDT syndrome who visited Quangang District Hospital of Quanzhou City from January 2024 to August 2025 were enrolled and randomly assigned to an observation group and a control group,with 56 cases in each group.The control group received routine intervention,whereas the observation group received comprehensive visual function rehabilitation training on the basis of routine intervention,including intelligent blink training,accommodation training,work environment optimization,and health education.Both groups underwent an 8-week intervention.The ocular surface disease index(OSDI),tear breakup time(TBUT),ocular protection index(OPI),visual fatigue scale(VFS) score,and work efficiency score were compared between the two groups before intervention and at 4 weeks and 8 weeks after intervention.Adverse reactions during the intervention period were recorded,and the clinical efficacy and safety of comprehensive visual function rehabilitation training were analyzed.Results Before intervention,there were no statistically significant differences between the two groups in OSDI score,TBUT,OPI,VFS score,or work efficiency score(P>0.05).At 4 and 8 weeks after intervention,both groups showed significantly lower OSDI and VFS scores than before intervention(P<0.05),and significantly higher TBUT,OPI,and work efficiency scores than before intervention(P<0.05).The improvements in these indicators were significantly greater in the observation group than in the control group(P<0.05).No obvious adverse reactions occurred in either group during the intervention period,and the intervention adherence of the observation group was significantly higher than that of the control group(94.64% VS 83.93%,P<0.05).Conclusion Comprehensive visual function rehabilitation training can effectively improve ocular surface symptoms in patients with dry eye disease and VDT syndrome,prolong tear breakup time,enhance ocular surface protection,relieve visual fatigue,and improve work efficiency.It is safe and associated with good patient adherence.
Objective To investigate the rehabilitative effect of Yin-Yang balance penetrating acupuncture combined with contralaterally controlled functional electrical stimulation(CCFES) in patients with post-stroke upper-limb spastic hemiplegia.Methods A retrospective study was conducted on 100 patients with upper-limb spastic hemiplegia after stroke treated at the Third Affiliated Hospital of Luohe Medical College from January to December 2025.According to the treatment regimen,all patients received routine rehabilitation therapy.Fifty patients treated with CCFES alone were assigned to the control group,and 50 patients treated with Yin-Yang balance penetrating acupuncture combined with CCFES were assigned to the observation group.After 4 weeks of treatment,the two groups were compared in terms of treatment efficacy,upper-limb function,upper-limb motor function and grasping ability(Fugl-Meyer assessment[FMA],action research arm test[ARAT],box and block test[BBT]),ratio of root mean square(RMS) values of upper-limb muscles,and quality of life (modified Barthel index[MBI]).Results After 4 weeks of treatment,the total effective rate in the observation group (94.00%) was higher than that in the control group(78.00%),and the difference was statistically significant(P<0.05).After 4 weeks of treatment,FMA,ARAT,and BBT scores in both groups were higher than those after 2 weeks of treatment and before treatment;moreover,the FMA,ARAT,and BBT scores in the observation group at 2 and 4 weeks were higher than those in the control group(P<0.05).After 4 weeks of treatment,the RMS ratios of the wrist extensor muscles and triceps brachii in both groups were higher than those before treatment and after 2 weeks of treatment;the observation group showed higher RMS ratios than the control group at 2 and 4 weeks(P<0.05).After 4 weeks of treatment,MBI scores in both groups were higher than those before treatment and after 2 weeks of treatment;the observation group also had higher MBI scores than the control group at 2 and 4 weeks(P<0.05).Conclusion In patients with post-stroke upper-limb spastic hemiplegia,treatment with Yin-Yang balance penetrating acupuncture combined with CCFES can restore upper-limb function and grasping ability,improve muscle RMS ratios,enhance quality of life,and promote rapid rehabilitation.
Objective To investigate the effects of probiotics combined with early enteral nutrition on early neurological recovery,correction of intestinal flora imbalance,and restoration of intestinal barrier function in patients with ischemic stroke.Methods A total of 120 patients with ischemic stroke admitted to Hainan West Central Hospital from January 2023 to June 2024 were enrolled and randomly assigned to a control group and a trial group,with 60 patients in each group.The control group received early enteral nutrition alone,while the trial group received probiotics in addition to early enteral nutrition.Changes in intestinal flora (Enterobacteriaceae and Bifidobacterium),intestinal barrier markers (serum intestinal fatty acid-binding protein[I-FABP],zonula occludens-1[ZO-1],and urinary lactulose/mannitol ratio[L/M]),and National Institutes of Health Stroke Scale(NIHSS) scores were assessed in both groups.The incidence of adverse events was also compared.Results After 2 weeks of treatment,the trial group showed better levels of Enterobacteriaceae (6.23±0.62)lg CFU/g and Bifidobacterium (8.09±0.49)lg CFU/g than the control group (7.06±0.70)lg CFU/g and (6.97±0.56)lg CFU/g,with statistically significant differences(P<0.05).After 2 weeks of treatment,the trial group also had better serum I-FABP (2.28±0.64)ng/mL,ZO-1 (4.09±0.81)ng/mL,and urinary L/M (0.032±0.007) levels than the control group (3.53±0.81)ng/mL,(2.84±0.70)ng/mL,and (0.054±0.009),with statistically significant differences(P<0.05).After 2 weeks of treatment,the NIHSS score in the trial group was lower than that in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse events was 11.67% in the trial group and 18.33% in the control group,with no statistically significant difference(P>0.05).Conclusion For patients with ischemic stroke,probiotics combined with early enteral nutrition can restore intestinal flora balance,repair intestinal barrier function,and promote neurological recovery.The combined regimen does not increase adverse events and has good safety.
Objective To analyze the therapeutic effect of acupuncture combined with Guizhi Fuling pills guided by the theory of phlegm-stasis interbinding in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 147 AECOPD patients of phlegm-stasis interbinding type admitted to Qijiang District Traditional Chinese Medicine Hospital in Chongqing from January 2025 to January 2026 were selected and divided into a Chinese medicine group,an acupuncture group,and a combined group according to the random number table,with 49 patients in each group.All three groups received conventional treatment.The Chinese medicine group was additionally treated with oral Guizhi Fuling pills,the acupuncture group was additionally treated with acupuncture therapy guided by the phlegm-stasis interbinding theory,and the combined group was additionally treated with a combination of Guizhi Fuling pills and acupuncture therapy.All interventions lasted for 14 days.Comparisons were made in terms of TCM syndrome scores,pulmonary function,blood gas parameters,immune function,and safety.Results After 14 days of intervention,the TCM syndrome score in the combined group was lower than that in the Chinese medicine group and the acupuncture group(P<0.05);the percentage of forced expiratory volume in one second to predicted value,forced vital capacity,and forced expiratory volume in one second/forced vital capacity levels were all higher than those in the Chinese medicine group and the acupuncture group(P<0.05);partial pressure of oxygen in blood and oxygen saturation were both higher than those in the Chinese medicine group and the acupuncture group,while partial pressure of carbon dioxide was lower than that in the Chinese medicine group and the acupuncture group (P<0.05);CD8+ was lower than that in the Chinese medicine group and the acupuncture group,while CD4+ and CD4+/CD8+ were both higher than those in the Chinese medicine group and the acupuncture group (P<0.05).There was no difference of statistical significance in safety data among the three groups(P>0.05).Conclusion Patients with acute exacerbation of chronic obstructive pulmonary disease who receive acupuncture combined with Guizhi Fuling pills under the guidance of the phlegm-stasis interbinding theory can significantly improve their traditional Chinese medicine syndrome scores,pulmonary function,blood gas parameters,and immune function compared to conventional treatment,and exhibit higher safety.
Objective To investigate the effect of a self-formulated Huoxue Xiaozhong capsule on postoperative pain after unilateral biportal endoscopic(UBE) spine surgery in patients with lumbar disc herniation of qi stagnation and blood stasis.Methods A total of 72 patients with postoperative pain after UBE for lumbar disc herniation (qi stagnation and blood stasis syndrome) admitted to Gongan Hospital of Traditional Chinese Medicine from June 2024 to December 2025 were enrolled.Using a random number table,they were assigned to a control group and an experimental group, with 36 patients in each group.The control group received routine postoperative treatment,while the experimental group received the self-formulated Huoxue Xiaozhong capsule in addition to the same routine treatment.Changes in traditional Chinese medicine(TCM) symptom scores, serum pain mediators (interleukin-17[IL-17] and prostaglandin E2 [PGE2]),visual analogue scale(VAS) scores,and Japanese Orthopaedic Association(JOA) scores were observed in both groups,and postoperative safety was evaluated. Results ①On postoperative day 14,the main symptom score,secondary symptom score, and total score of TCM symptom were significantly lower in the experimental group than in the control group(P<0.05).②On postoperative day 14, IL-17 and PGE2 levels,as well as VAS scores,were significantly lower in the experimental group than in the control group(P<0.05).③On postoperative day 14,the JOA score was significantly higher in the experimental group than in the control group(P<0.05).④The incidence of adverse reactions in the experimental group was comparable to the control group(16.67% VS 13.89%, P>0.05).Conclusion For patients with postoperative pain after UBE for lumbar disc herniation and qi stagnation and blood stasis syndrome,treatment with the self-formulated Huoxue Xiaozhong capsule can reduce serum pain mediator levels,effectively relieve symptoms and pain,improve lumbar function,and demonstrate good safety.
Objective To investigate the clinical efficacy of the modified dioscorea pills combined with Trelegy Ellipta(fluticasone furoate/umeclidinium/vilanterol) in the treatment of lung-kidney deficiency syndrome in lung distension disease.Methods A total of 60 patients admitted to Yunyang County Hospital of Traditional Chinese Medicine from April 2024 to April 2025 were selected for the study.They were divided into a control group and a treatment group according to the random number table,with 30 cases in each group.The control group was treated with Trelegy Ellipta inhalation powder,while the treatment group was additionally treated with the modified dioscorea pills on this basis.Results After treatment,the clinical symptom scores and pulmonary function indicators (forced vital capacity[FVC],forced expiratory volume in one second[FEV1],and percentage of FEV1 to predicted value [FEV1%]) in the treatment group were superior to those in the control group ([3.68±0.31]L,[2.12±0.34]L,[74.95±13.64]% VS [3.15±0.33]L,[1.83±0.50]L,[66.84±12.51]%),with differences of statistical significance(P<0.05).Furthermore,the clinical efficacy was significantly better in the treatment group than in the control group(P<0.05).Conclusion The combination of modified dioscorea pills and Trelegy Ellipta can effectively improve patients' clinical symptoms and pulmonary function through the synergistic effect of traditional Chinese and Western medicine,enhancing clinical efficacy and providing new ideas and methods for the treatment of lung-kidney deficiency syndrome in lung distension disease.
This study explores the integration of the traditional Chinese medicine(TCM) Theory of Body Fluids with modern sports nutrition,aiming to construct an integrated TCM and Western medicine rehydration strategy suitable for special service personnel in high-temperature environments.By systematically reviewing modern research on high-temperature exercise physiology,dehydration mechanisms and rehydration strategies,as well as the theoretical connotations and modern evidence of TCM concepts such as body fluids (Jinye) and deficiency of both qi and yin,this study finds that the clinical manifestations of exercise-induced dehydration in high-temperature environments are highly consistent with the TCM syndrome of deficiency of both qi and yin.The sweating threshold and sweating sensitivity in modern physiology can correspond to the strength or weakness of healthy qi (Zheng qi) and the abundance or deficiency of body fluids in TCM,respectively.On this basis,a stratified and individualized comprehensive intervention program is proposed: before exercise,the goal is to achieve euhydration,and TCM pre-intervention for replenishing qi and nourishing yin is administered when necessary;during exercise,fluids containing sodium and carbohydrates are supplemented in a stratified manner according to exercise duration and intensity,and sensory cooling methods such as menthol are applied appropriately;during the recovery period,the principle of surplus rehydration is implemented,and TCM beverages with the effect of transforming yin through sour-sweet combination are recommended to promote saliva secretion and enhance body fluid retention.This strategy extends the focus from simple water and salt supplementation to replenishing qi,nourishing yin,promoting fluid production and relieving thirst,providing a theoretical reference and practical approach to addressing both the physiological and subjective problems of exercise-induced dehydration in high-temperature environments.
Sleep plays vital physiological functions.Special factors in plateau environments,such as hypoxia and low pressure,directly interfere with the human sleep-wake rhythm and destroy sleep structure,leading to sleep disorders including difficulty falling asleep,fragmented sleep,and insufficient total sleep time,which seriously affect the sleep health of people on plateaus.Long-term sleep disorders increase health risks in the cardiovascular system,mental health,cognition,memory consolidation,immunity,reproduction,and hormonal regulation.At present,there is still a lack of systematic research on the prevention and intervention measures for plateau sleep disorders,and relevant diagnosis and treatment norms have not been fully established.This paper reviews the pathogenesis of plateau sleep disorders,the application of sedative-hypnotic drugs and plateau-specific preventive and therapeutic drugs,as well as non-pharmacological interventions that can effectively improve plateau sleep disorders,such as transcranial magnetic stimulation,biofeedback,cognitive therapy,thermal insulation,oxygen inhalation,and sleep hygiene behavioral interventions.It also constructively proposes future research directions for the prevention of plateau sleep disorders,providing a reference for improving sleep quality on plateaus.
Pulmonary hypertension(PH) is a complex cardiopulmonary vascular syndrome characterized by an abnormal elevation of mean pulmonary arterial pressure at rest,which can lead to a continuous increase in the afterload of the right ventricle,ultimately progress to right heart failure and even death.It severely impairs patients' exercise tolerance and long-term quality of life.Currently,the pathogenesis of PH has not been fully elucidated,and conventional Western medicine treatment strategies often suffer from strong clinical dependence,numerous side effects,and an inability to reverse established pulmonary vascular remodeling.Traditional Chinese Medicine(TCM) exhibits unique theoretical value and application prospects in the prevention and treatment of PH.Based on the core principles of "holistic concept" and "treatment based on syndrome differentiation",TCM exerts a significant therapeutic effect on PH through integrated regulatory effects of multiple components,multiple targets,and multiple pathways.This article systematically combs through the research trends on TCM intervention for PH in recent years,summarizes the theoretical understanding of PH from the perspective of TCM pathogenesis,and focuses on cutting-edge explorations of TCM intervention mechanisms.It conducts an in-depth discussion from the aspects of single Chinese herbs,Chinese herbal formulas,and other TCM therapies such as acupuncture,acupoint application,and catgut embedding,aiming to provide scientific references for optimizing TCM-based strategies for the prevention and treatment of PH.
In recent years,China has witnessed a continuously deepening and accelerating population aging process.This has posed unprecedented challenges to the traditional public service supply system.Currently,the elderly care demand in communities is rapidly shifting from a single focus on daily living care to full cycle,comprehensive and diversified integrated medical and elderly care services.However,China has long been plagued by a service structure characterized by "separated medical and elderly care services" and "vertical and horizontal fragmentation".This has hindered the effective integration of medical resources and elderly care services.It fails to meet the elderly's practical expectation of "receiving medical care nearby and receiving continuous care",while also leading to a mismatch in the allocation and inefficient utilization of medical and elderly care resources.Therefore,as a modern and socialized new model of elderly care services proposed at this stage in China,"Integrated Medical and Elderly Care",which combines the development of medical health and elderly care services,has become a key measure to actively implement the national strategy for coping with population aging.It better meets the health and elderly care needs of the elderly in communities.This article analyzes and elaborates on the research progress of community-based integrated medical and elderly care from aspects such as the definition of connotation,policy system,and service models.It points out the need to further deepen practical exploration in areas such as policy guarantee,distinctive models,and talent teams.The ultimate goal is to fundamentally enhance the equalization,professionalism,and sustainability of community-based integrated medical and elderly care services,thereby providing a systematic solution to the elderly care dilemma in a deeply aging society.
With the deepening of population aging in China,mild cognitive impairment(MCI) has become a major public health problem affecting the health of elderly people and imposing a significant social and medical burden.This article systematically retrieves and synthesizes relevant domestic research literature,and reviews the prevalence status,influencing factors,and research progress of MCI in elderly people in China from two major dimensions: internal and external factors.The results show that internal factors such as age,gender,lifestyle,physical function,and chronic underlying diseases,as well as external factors including education level,occupation type,income level,and social environment,are closely associated with the incidence and development of MCI in elderly people.Current domestic research has gradually shifted from single-factor analysis to multi-dimensional and multi-level discussions.However,problems remain,such as insufficient integration of influencing factors and lack of specificity in intervention measures.Future research should further improve the MCI risk factor assessment system,strengthen interdisciplinary cooperation,and establish a sound social support network for elderly cognitive health.This aims to reduce the incidence of MCI,delay the progression of dementia,and provide scientific evidence for promoting healthy aging.
With the accelerated global aging process,the number of disabled elderly people in China has exceeded 40 million and continues to grow.Over half of them reside in rural areas,and home-based care serves as the primary elderly care model for this population.A scientific and comprehensive quality evaluation index system is crucial to improving the care quality for the disabled elderly,and has thus become a key research focus across multiple disciplines including nursing and public health.Previous studies have mostly focused on institutional care and community-based elderly care settings,while attention to the field of rural home-based care remains insufficient.Countries such as the United States,Australia,and Germany have established systematic,multi-dimensional long-term care quality evaluation frameworks,providing valuable references for China to develop an indigenous index system.Based on the three-dimensional quality structure model,this paper reviews the current research status of care quality evaluation index systems for the disabled elderly at home and abroad,and summarizes the core dimensional differences between domestic and international systems.Furthermore,incorporating the characteristics of China's rural care resource allocation,it proposes a framework for constructing an index system tailored to home-based care for rural disabled elderly in China.
