Objective To investigate the effects of early continuous renal replacement therapy(CRRT) on the improvement of clinical symptoms,inflammatory factors and prognosis of severe acute pancreatitis(SAP).Methods A total of 110 SAP patients admitted to Shangqiu No.3 People's Hospital from January 2022 to January 2023 were selected as the study subjects.They were assigned into control group(n=55) and observation group(n=55) according to different treatment regimens.Patients in the control group were treated with conventional Western medicine,and those in the observation group were treated with conventional Western medicine combined with CRRT.The clinical efficacy,time of clinical symptom improvement,health status(acute physiology and chronic health evaluation Ⅱ [APACHE Ⅱ],modified Marshall organ failure score,ranson's criteria for pancreatitis mortality),inflammatory factors(procalcitonin [PCT],interleukin-17 [IL-17],high mobility group protein B1 [HMGB1]),urinary amylase,and immune function(CD₃⁺,CD₄⁺,immunoglobulin A [IgA],immunoglobulin G [IgG],immunoglobulin M [IgM]) before and after treatment were compared.The incidence of complications was compared between the two groups as well.Results The total effective rate of the observation group was significantly higher than that of control group(92.73% VS 72.73%,P<0.05).The time of clinical symptom improvement was significantly shorter in the observation group than that of the control group(P<0.05).After treatment,patients in the observation group had significantly lower APACHE Ⅱ([3.87±1.19]points VS [7.42±2.17]points),modified Marshall organ failure score([1.08±0.33]points VS [1.76±0.49]points) and Ranson's Criteria for pancreatitis mortality([1.37±0.35]points VS [2.29±0.63]points) than those of control group(P<0.05).PCT([1.57±0.42]μg/L VS [3.08±0.92]μg/L),IL-17([10.32±2.86]ng/L VS [20.71±5.91]ng/L),HMGB1([3.16±0.85]ng/mL VS [7.09±1.13]ng/mL) and urinary amylase([103.65±30.55]U/L VS [148.74±39.58]U/L) after treatment were significantly lower in the observation group than those of control group(P<0.05).CD₃⁺([69.65%±8.32]% VS [62.07%±9.03]%),CD₄⁺([37.49%±6.49]% VS [32.07%±5.69]%) and IgA([12.86±3.28]g/L VS [7.26±2.13]g/L) were significantly higher,while IgG([1.22±0.30]g/L VS [5.94±1.28]g/L) and IgM([1.17±0.28]g/L VS [1.88±0.42]g/L) were significantly lower in the observation group than those of control group(P<0.05).There was no significant difference in the rate of complications between the two groups(P>0.05).Conclusion Early CRRT is effective and safe in the treatment of SAP,which can improve clinical symptoms,promote disease rehabilitation,correct the disorder of inflammatory factor-urine amylase level,and improve immune function.