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›› 2021, Vol. 30 ›› Issue (12): 0-0.

• 临床研究 •    

红细胞体积分布宽度、髓过氧化物酶与老年阻塞性睡眠呼吸暂停综合征严重程度的关系

党晶芸   

  1. 郑州大学第一附属医院
  • 收稿日期:2021-04-22 修回日期:2021-06-11 出版日期:2021-12-30 发布日期:2021-10-21
  • 通讯作者: 党晶芸
  • 基金资助:
    口咽肌功能训练项目对头颈部肿瘤术后患者合并阻塞性睡眠呼吸暂停低通气综合征的作用

Relationship between red blood cell distribution width, myeloperoxidase and severity of obstructive sleep apnea syndrome in the elderly

  • Received:2021-04-22 Revised:2021-06-11 Online:2021-12-30 Published:2021-10-21

摘要: 目的 探讨红细胞体积分布宽度(RDW)、髓过氧化物酶(MPO)与老年阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrom,OSAS)严重程度的关系。方法 选取2018年11月至2020年11月在郑州大学第一附属医院就诊的132例老年OSAS患者(OSAS组),以及同期体检排除OSAS的64例老年人(对照组)。所有研究对象均在入院后进行睡眠呼吸监测,记录呼吸暂停低通气指数(AHI),并根据AHI将OSAS患者进一步分为轻度(5~14次/h)、中度(15~29次/h)和重度(≥30次/h);另采集睡眠呼吸监测日清晨空腹静脉血,行血常规检查,并使用酶联免疫吸附法(ELISA)检测血清MPO水平。结果 OSAS组RDW[(14.15±1.21)% VS (12.92±1.35)%]及血清MPO[(85.38±19.60)ug/L VS (41.86±7.92)ug/L]水平均显著高于对照组(P<0.05);轻度、中度和重度OSAS患者的RDW[(13.54±1.38)%、(14.06±1.27)%、(15.16±0.95)%]和血清MPO[(54.75±10.87)ug/L、(87.92±18.56)ug/L、(124.07±28.73)ug/L]水平差异均有统计学意义(P<0.05),随着病情程度加重,RDW及血清MPO水平逐渐升高,各组间比较差异有统计学意义(均P<0.05);Pearson相关分析显示RDW及血清MPO水平均与AHI呈显著正相关(均P<0.05)。结论 RDW及血清MPO水平均与老年OSAS严重程度呈正相关,可能作为老年OSAS严重程度评估的潜在指标。

关键词: 阻塞性睡眠呼吸暂停综合征, 严重程度, 红细胞体积分布宽度, 髓过氧化物酶, Obstructive sleep apnea syndrome, Severity, Red blood cell distribution width, Myeloperoxidase

Abstract: To explore the relationship between red blood cell distribution width (RDW), myeloperoxidase (MPO) and the severity of obstructive sleep apnea syndrome (OSAS) in the elderly. Methods: A total of 132 elderly patients with OSAS (OSAS group) and 64 elderly patients without OSAS (control group) undergoing physical examination in First Affiliated Hospital of Zhengzhou University from November 2018 to November 2020 were enrolled. All underwent underwent polysomnography after admission to record apnea-hypopnea index (AHI). According to AHI, OSAS patients were further divided into mild group (5-14 times/h), moderate group (15-29 times/h) and severe group (≥30 times/h). The fasting venous blood in the morning on polysomnography day was collected for routine blood examination. The level of serum MPO was detected by enzyme-linked immunosorbent assay (ELISA). Results: The levels of RDW [(14.15±1.21) % vs (12.92±1.35) %] and serum MPO [(85.38±19.60) ug/L vs (41.86±7.92) ug/L] in OSAS group were significantly higher than those in control group (P<0.05). The differences in levels of RDW [(13.54±1.38) %, (14.06±1.27) %, (15.16±0.95) %] and serum MPO [(54.75±10.87) ug/L, (87.92±18.56) ug/L, (124.07±28.73) ug/L] among mild, moderate and severe groups were statistically significant (P<0.05). As the exacerbation of conditions, levels of RDW and serum MPO were gradually increased, and there were significant differences among all groups (P<0.05). Pearson correlation analysis showed that levels of RDW and serum MPO were significantly positively correlated with AHI (P<0.05). Conclusion: The levels of RDW and serum MPO are positively correlated with OSAS severity in the elderly, which may be applied as potential indexes to assess the severity of OSAS.