Objective: To observe the clinical effect of Shen Song Yangxin Capsule Combined with metoprolol sustained-release tablets in the treatment of senile arrhythmia. Methods: 76 elderly patients with arrhythmia in our hospital from June 2016 to August 2017 were selected and divided into combined group and control group, with 38 people in each group. All patients were treated with metoprolol sustained release tablets. On this basis, the patients in the combined group were treated with Shen Song Yangxin capsule, 4, TID, and 3 weeks. At the beginning and end of the treatment, the patients were examined by 24 hour dynamic electrocardiogram (ECG), and the symptoms and adverse reactions were observed. Results: the treatment effect, arrhythmia frequency and symptom improvement of the combined group were significantly better than those of the control group, and there was no obvious adverse reaction. Conclusion: the application of Shen Song Yangxin Capsule Combined with metoprolol sustained-release tablets in the treatment of senile arrhythmia can significantly increase the efficacy and safety.